InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ces1d

Summary

InnateDB Protein

IDBP-180670.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ces1d

Protein Name

carboxylesterase 1D

Synonyms

Ces3; TGH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034172

InnateDB Gene

IDBG-180668 (Ces1d)

Protein Structure

UniProt Annotation

Function

Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. {ECO:0000269PubMed:15220344}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000269PubMed:15220344}. Cytoplasm, cytosol {ECO:0000269PubMed:15220344}. Lipid droplet {ECO:0000269PubMed:15220344}.

Disease Associations

Tissue Specificity

Highest expression occurs in liver with lower levels in adipose tissue, kidney, heart, intestine, lung, testis and thymus. {ECO:0000269PubMed:11470237, ECO:0000269PubMed:15269189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004771	sterol esterase activity
GO:0004806	triglyceride lipase activity
GO:0016787	hydrolase activity
GO:0030339	fatty-acyl-ethyl-ester synthase activity
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0006637	acyl-CoA metabolic process
GO:0008152	metabolic process
GO:0009636	response to toxic substance
GO:0016042	lipid catabolic process
GO:0019626	short-chain fatty acid catabolic process
GO:0034379	very-low-density lipoprotein particle assembly
GO:0046464	acylglycerol catabolic process