Version 5.4
Mus musculus Gene: Ces1d
Summary
InnateDB Gene IDBG-180668.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ces1d
Gene Name carboxylesterase 1D
Synonyms Ces3; TGH
Species Mus musculus
Ensembl Gene ENSMUSG00000056973
Encoded Proteins
IDBP-180670
carboxylesterase 1D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198848:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:93166068-93197838
Strand Reverse strand
Band C5
Transcripts
ENSMUST00000034172 ENSMUSP00000034172
ENSMUST00000143256
ENSMUST00000148340
ENSMUST00000129987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004771 sterol esterase activity
GO:0004806 triglyceride lipase activity
GO:0016787 hydrolase activity
GO:0030339 fatty-acyl-ethyl-ester synthase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006637 acyl-CoA metabolic process
GO:0008152 metabolic process
GO:0009636 response to toxic substance
GO:0016042 lipid catabolic process
GO:0019626 short-chain fatty acid catabolic process
GO:0034379 very-low-density lipoprotein particle assembly
GO:0046464 acylglycerol catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005811 lipid particle
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000198848
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu00983
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.292803
RefSeq NM_053200
OMIM
CCDS CCDS22528
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca