InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rragb

Summary

InnateDB Protein

IDBP-180685.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rragb

Protein Name

Ras-related GTP binding B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039013

InnateDB Gene

IDBG-180683 (Rragb)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250UniProtKB:Q5VZM2}. Lysosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0032561	guanyl ribonucleotide binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032008	positive regulation of TOR signaling
GO:0034613	cellular protein localization
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:3038613

InterPro

IPR001806 Small GTPase superfamily
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670

PRINTS

PR00449
PR00328

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6NTA4