InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cpb2

Summary

InnateDB Protein

IDBP-180761.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpb2

Protein Name

carboxypeptidase B2 (plasma)

Synonyms

1110032P04Rik; 4930405E17Rik; AI255929; CPR; Cpu; TAFI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022576

InnateDB Gene

IDBG-180759 (Cpb2)

Protein Structure

UniProt Annotation

Function

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

Subcellular Localization

Secreted {ECO:0000269PubMed:10739389}.

Disease Associations

Tissue Specificity

Plasma; synthesized in the liver. {ECO:0000269PubMed:10739389}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0003331	positive regulation of extracellular matrix constituent secretion
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0009408	response to heat
GO:0010757	negative regulation of plasminogen activation
GO:0042493	response to drug
GO:0042730	fibrinolysis
GO:0051918	negative regulation of fibrinolysis
GO:0071333	cellular response to glucose stimulus
GO:0097421	liver regeneration
GO:2000346	negative regulation of hepatocyte proliferation

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

MGI:1891837

InterPro

IPR000834 Peptidase M14, carboxypeptidase A
IPR003146 Proteinase inhibitor, carboxypeptidase propeptide
IPR009020 Proteinase inhibitor, propeptide

PFAM

PF00246
PF02244

PRINTS

PR00765

PIRSF

SMART

SM00631

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JHH6

PhosphoSite

PhosphoSite-Q9JHH6

TrEMBL

UniProt Splice Variant

Entrez Gene

56373

UniGene

RefSeq

NP_062749

MGI ID

MGI Symbol

Cpb2

OMIM

CCDS

CCDS27277

HPRD

IMGT

EMBL

AB021968 AF164524 AF186188 AK004045 BC089577

GenPept

AAF00528 AAF62385 AAH89577 BAB03402 BAB23141