Version 5.4
Mus musculus Gene: Cpb2
Summary
InnateDB Gene IDBG-180759.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpb2
Gene Name carboxypeptidase B2 (plasma)
Synonyms 1110032P04Rik; 4930405E17Rik; AI255929; CPR; Cpu; TAFI
Species Mus musculus
Ensembl Gene ENSMUSG00000021999
Encoded Proteins
IDBP-180761
carboxypeptidase B2 (plasma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080618:
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. [provided by RefSeq, Apr 2012]
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:75242287-75283551
Strand Forward strand
Band D3
Transcripts
ENSMUST00000022576 ENSMUSP00000022576
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0003331 positive regulation of extracellular matrix constituent secretion
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0009408 response to heat
GO:0010757 negative regulation of plasminogen activation
GO:0042493 response to drug
GO:0042730 fibrinolysis
GO:0051918 negative regulation of fibrinolysis
GO:0071333 cellular response to glucose stimulus
GO:0097421 liver regeneration
GO:2000346 negative regulation of hepatocyte proliferation
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000080618
View Gene Order
ENSBTAG00000007073
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu04974
Protein digestion and absorption pathway
mmu04972
Pancreatic secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa04972
Pancreatic secretion pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt Q9JHH6
TrEMBL
UniProt Splice Variant
Entrez Gene 56373
UniGene
RefSeq NM_019775
OMIM
CCDS CCDS27277
HPRD
IMGT
MGI ID MGI:1891837
MGI Symbol Cpb2
EMBL AB021968 AF164524 AF186188 AK004045 BC089577
GenPept AAF00528 AAF62385 AAH89577 BAB03402 BAB23141
RNA Seq Atlas 56373

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca