Version 5.4
Mus musculus Protein: Sike1
Summary
InnateDB Protein IDBP-180779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sike1
Protein Name suppressor of IKBKE 1
Synonyms 2810005O12Rik; 5730470L24Rik; AI450236; AI839862; Sike; Sikeb;
Species Mus musculus
Ensembl Protein ENSMUSP00000029447
InnateDB Gene IDBG-180777 (Sike1)
Protein Structure
UniProt Annotation
Function Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1913891
InterPro IPR008555 Suppressor of IKBKE 1
PFAM PF05769
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CPR7
PhosphoSite PhosphoSite-Q9CPR7
TrEMBL
UniProt Splice Variant
Entrez Gene 66641
UniGene Mm.467753
RefSeq NP_079955
MGI ID
MGI Symbol Sike1
OMIM
CCDS CCDS17690
HPRD
IMGT
EMBL AK014113 AK014247 AK017694 AK019264 AK033553 AK035590 BC004090
GenPept AAH04090 BAB29165 BAB29223 BAB30879 BAB31636 BAC28353 BAC29116

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca