InnateDB Protein
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IDBP-180795.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rfx4
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Protein Name
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regulatory factor X, 4 (influences HLA class II expression)
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Synonyms
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4933412G19Rik; NYD-sp10;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000051107
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InnateDB Gene
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IDBG-180793 (Rfx4)
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Protein Structure
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Function |
Plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. {ECO:0000269PubMed:12925582, ECO:0000269PubMed:16893423}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00858, ECO:0000269PubMed:14701801}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is brain-specific. Isoform 2 is testis-specific. Isoform 1 is highly expressed in the suprachiasmatic nucleus (at protein level), the central pacemaker site of the circadian clock. {ECO:0000269PubMed:12925582, ECO:0000269PubMed:14701801}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0021516
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dorsal spinal cord development
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GO:0021537
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telencephalon development
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GO:0021696
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cerebellar cortex morphogenesis
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GO:0021914
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negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
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GO:0030900
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forebrain development
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GO:0030901
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midbrain development
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GO:0042384
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cilium assembly
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0070613
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regulation of protein processing
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Cellular Component |
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PDB ID |
MGI:1918387
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InterPro |
IPR003150
DNA-binding RFX-type winged-helix domain
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PFAM |
PF02257
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TNK1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
71137
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UniGene |
Mm.79070
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RefSeq |
NP_001020089
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MGI ID |
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MGI Symbol |
Rfx4
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OMIM |
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CCDS |
CCDS24082
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HPRD |
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IMGT |
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EMBL |
AB086957
AB089184
AK016791
AK034131
AK132673
AY102010
AY342003
BC138719
BC138720
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GenPept |
AAI38720
AAI38721
AAM52485
AAQ17042
BAB30432
BAC28598
BAD07408
BAD07409
BAE21294
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