Version 5.4
Mus musculus Gene: Rfx4
Summary
InnateDB Gene IDBG-180793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rfx4
Gene Name regulatory factor X, 4 (influences HLA class II expression)
Synonyms 4933412G19Rik; NYD-sp10
Species Mus musculus
Ensembl Gene ENSMUSG00000020037
Encoded Proteins
IDBP-180795
regulatory factor X, 4 (influences HLA class II expression)
IDBP-180797
regulatory factor X, 4 (influences HLA class II expression)
IDBP-624701
regulatory factor X, 4 (influences HLA class II expression)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111783:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:84756062-84906538
Strand Forward strand
Band C1
Transcripts
ENSMUST00000060397 ENSMUSP00000051107
ENSMUST00000095388 ENSMUSP00000093035
ENSMUST00000020226
ENSMUST00000165868
ENSMUST00000173479
ENSMUST00000166696 ENSMUSP00000128690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0021516 dorsal spinal cord development
GO:0021537 telencephalon development
GO:0021696 cerebellar cortex morphogenesis
GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0042384 cilium assembly
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070613 regulation of protein processing
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111783
View Gene Order
ENSBTAG00000025837
Not yet available
Cross-References
SwissProt Q7TNK1
TrEMBL
UniProt Splice Variant
Entrez Gene 71137
UniGene Mm.399220 Mm.79070
RefSeq XM_006514113 XM_006514114 XM_006514115 NM_001024918 NM_027689
OMIM
CCDS CCDS24082 CCDS24083
HPRD
IMGT
MGI ID MGI:1918387
MGI Symbol Rfx4
EMBL AB086957 AB089184 AK016791 AK034131 AK132673 AY102010 AY342003 BC138719 BC138720
GenPept AAI38720 AAI38721 AAM52485 AAQ17042 BAB30432 BAC28598 BAD07408 BAD07409 BAE21294
RNA Seq Atlas 71137

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca