InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubqln2

Summary

InnateDB Protein

IDBP-180837.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubqln2

Protein Name

ubiquilin 2

Synonyms

Chap1; Dsk2; HRIHFB2157; Plic-2; Plic2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056888

InnateDB Gene

IDBG-180835 (Ubqln2)

Protein Structure

UniProt Annotation

Function

Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation (By similarity). Links CD47 to vimentin- containing intermediate filaments of the cytoskeleton. {ECO:0000250, ECO:0000269PubMed:10549293}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10549293}. Nucleus {ECO:0000269PubMed:10549293}. Membrane {ECO:0000269PubMed:10549293}. Note=Associated with fibers and membrane-associated.

Disease Associations

Tissue Specificity

Highly expressed in smooth muscle. Expression in other tissues is very low. {ECO:0000269PubMed:10549293}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006289	nucleotide-excision repair
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1860283

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000626 Ubiquitin-like
IPR006636 Heat shock chaperonin-binding
IPR009060 UBA-like
IPR015360 XPC-binding domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016024 Armadillo-type fold
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00627
PF00240
PF14560
PF09280
PF11976

PRINTS

PIRSF

SMART

SM00213
SM00727
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QZM0