Version 5.4
Mus musculus Gene: Ubqln2
Summary
InnateDB Gene IDBG-180835.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubqln2
Gene Name ubiquilin 2
Synonyms Chap1; Dsk2; HRIHFB2157; Plic-2; Plic2
Species Mus musculus
Ensembl Gene ENSMUSG00000050148
Encoded Proteins
IDBP-180837
ubiquilin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188021:
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153498227-153501570
Strand Forward strand
Band F3
Transcripts
ENSMUST00000060714 ENSMUSP00000056888
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006289 nucleotide-excision repair
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188021
View Gene Order
ENSBTAG00000021843
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9QZM0
TrEMBL
UniProt Splice Variant
Entrez Gene 54609
UniGene Mm.430772
RefSeq NM_018798
OMIM
CCDS CCDS30482
HPRD
IMGT
MGI ID MGI:1860283
MGI Symbol Ubqln2
EMBL AF177346 AL844583 BC021824 BC053022 CH466653
GenPept AAF01366 AAH21824 AAH53022 CAM18356 EDL31351
RNA Seq Atlas 54609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca