Version 5.4
Mus musculus Protein: Hnrnpf
Summary
InnateDB Protein IDBP-181208.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnrnpf
Protein Name heterogeneous nuclear ribonucleoprotein F
Synonyms 4833420I20Rik; AA407306; Hnrpf;
Species Mus musculus
Ensembl Protein ENSMUSP00000045048
InnateDB Gene IDBG-181206 (Hnrnpf)
Protein Structure
UniProt Annotation
Function Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 82 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003727 single-stranded RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
Protein Structure and Domains
PDB ID MGI:2138741
InterPro IPR000504 RNA recognition motif domain
IPR012996 Zinc finger, CHHC-type
PFAM PF00076
PF08080
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z2X1
PhosphoSite PhosphoSite-Q9Z2X1
TrEMBL Q8R582
UniProt Splice Variant
Entrez Gene 98758
UniGene Mm.422979
RefSeq NP_598595
MGI ID 2DB1
MGI Symbol Hnrnpf
OMIM
CCDS CCDS20467
HPRD
IMGT
EMBL AC153918 AK076478 BC018185 BC023162 BC025481 BC027003 BC029163 BC029764 BC033483 BC089313
GenPept AAH18185 AAH23162 AAH25481 AAH27003 AAH29163 AAH29764 AAH33483 AAH89313 BAC36361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca