InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nudt21

Summary

InnateDB Protein

IDBP-181368.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nudt21

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 21

Synonyms

25kDa; 3110048P04Rik; 5730530J16Rik; AU014860; AW549947; Cpsf5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034204

InnateDB Gene

IDBG-181366 (Nudt21)

Protein Structure

UniProt Annotation

Function

Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	81 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0017091	AU-rich element binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0044822	poly(A) RNA binding