Version 5.4
Mus musculus Protein: Nosip
Summary
InnateDB Protein IDBP-181400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nosip
Protein Name nitric oxide synthase interacting protein
Synonyms 2310061K06Rik; CGI-25;
Species Mus musculus
Ensembl Protein ENSMUSP00000003513
InnateDB Gene IDBG-181398 (Nosip)
Protein Structure
UniProt Annotation
Function Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0051001 negative regulation of nitric-oxide synthase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1913644
InterPro IPR016818 Nitric oxide synthase-interacting
PFAM
PRINTS
PIRSF PIRSF023577
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D6T0
PhosphoSite PhosphoSite-Q9D6T0
TrEMBL
UniProt Splice Variant
Entrez Gene 66394
UniGene Mm.272139
RefSeq NP_079809
MGI ID
MGI Symbol Nosip
OMIM
CCDS CCDS21228
HPRD
IMGT
EMBL AK007962 AK010006 BC089029
GenPept AAH89029 BAB25373 BAB26637

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca