InnateDB Protein
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IDBP-181499.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cdc20
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Protein Name
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cell division cycle 20 homolog (S. cerevisiae)
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Synonyms
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2310042N09Rik; C87100; p55CDC;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000006565
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InnateDB Gene
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IDBG-181497 (Cdc20)
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Protein Structure
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Function |
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. {ECO:0000269PubMed:19900895}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
92 [view]
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Molecular Function |
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Biological Process |
GO:0007067
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mitotic nuclear division
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GO:0008284
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positive regulation of cell proliferation
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GO:0016567
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protein ubiquitination
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0031915
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positive regulation of synaptic plasticity
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GO:0040020
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regulation of meiosis
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GO:0050773
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regulation of dendrite development
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GO:0051488
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activation of anaphase-promoting complex activity
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GO:0090129
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positive regulation of synapse maturation
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Cellular Component |
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PDB ID |
MGI:1859866
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JJ66
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PhosphoSite |
PhosphoSite-Q9JJ66
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
107995
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UniGene |
Mm.399777
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RefSeq |
NP_075712
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MGI ID |
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MGI Symbol |
Cdc20
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OMIM |
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CCDS |
CCDS18551
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HPRD |
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IMGT |
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EMBL |
AB045313
AF312208
AK075998
AK076030
AK083459
AK168650
BC003215
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GenPept |
AAH03215
AAL25714
BAA97451
BAC36109
BAC36132
BAC38922
BAE40507
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