Version 5.4
Mus musculus Gene: Cdc20
Summary
InnateDB Gene IDBG-181497.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc20
Gene Name cell division cycle 20
Synonyms 2310042N09Rik; C87100; p55CDC
Species Mus musculus
Ensembl Gene ENSMUSG00000006398
Encoded Proteins
IDBP-181499
cell division cycle 20 homolog (S. cerevisiae)
IDBP-789954
cell division cycle 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117399:
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:118432901-118437352
Strand Reverse strand
Band D2.1
Transcripts
ENSMUST00000006565 ENSMUSP00000006565
ENSMUST00000151302
ENSMUST00000183942 ENSMUSP00000139345
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 92 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0019899 enzyme binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0008284 positive regulation of cell proliferation
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031915 positive regulation of synaptic plasticity
GO:0040020 regulation of meiosis
GO:0050773 regulation of dendrite development
GO:0051488 activation of anaphase-promoting complex activity
GO:0090129 positive regulation of synapse maturation
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117399
View Gene Order
ENSBTAG00000009819
Not yet available
Pathways
NETPATH
REACTOME
REACT_215601
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_222875
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_222604
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_204224
Phosphorylation of Emi1 pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_230745
Immune System pathway
REACT_241408
M Phase pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_203517
SCF-beta-TrCP mediated degradation of Emi1 pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_246476
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_226135
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_219897
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_248037
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_229531
Adaptive Immune System pathway
REACT_234036
Mitotic Spindle Checkpoint pathway
REACT_202512
Mitotic Anaphase pathway
REACT_263475
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_210462
APC/C:Cdc20 mediated degradation of Cyclin B pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04110
Cell cycle pathway
mmu04114
Oocyte meiosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1072
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_1041
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_6820
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_6871
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6867
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_6821
SCF-beta-TrCP mediated degradation of Emi1 pathway
REACT_6875
Phosphorylation of Emi1 pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_023223
OMIM
CCDS CCDS18551
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca