InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fcgrt

Summary

InnateDB Protein

IDBP-181536.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fcgrt

Protein Name

Fc receptor, IgG, alpha chain transporter

Synonyms

FcRn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003512

InnateDB Gene

IDBG-181534 (Fcgrt)

Protein Structure

UniProt Annotation

Function

Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Intestinal epithelium of suckling rodents. Expressed in neonatal intestine and fetal yolk sac.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0005515	protein binding
GO:0019770	IgG receptor activity
GO:0019864	IgG binding
GO:0030881	beta-2-microglobulin binding

Biological Process

GO:0002416	IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0038094	Fc-gamma receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:103017

InterPro

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein

PFAM

PF00129
PF07654

PRINTS

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61559