Version 5.4
Mus musculus Gene: Fcgrt
Summary
InnateDB Gene IDBG-181534.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcgrt
Gene Name Fc receptor, IgG, alpha chain transporter
Synonyms FcRn
Species Mus musculus
Ensembl Gene ENSMUSG00000003420
Encoded Proteins
IDBP-181536
Fc receptor, IgG, alpha chain transporter
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104870:
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45092993-45103822
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000003512 ENSMUSP00000003512
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0005515 protein binding
GO:0019770 IgG receptor activity
GO:0019864 IgG binding
GO:0030881 beta-2-microglobulin binding
Biological Process
GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0038094 Fc-gamma receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104870
View Gene Order
ENSBTAG00000013926
Not yet available
Cross-References
SwissProt Q61559
TrEMBL Q6PKB0
UniProt Splice Variant
Entrez Gene 14132
UniGene Mm.3303 Mm.470885
RefSeq NM_010189 XM_006540603
OMIM
CCDS CCDS52243
HPRD
IMGT
MGI ID MGI:103017
MGI Symbol Fcgrt
EMBL BC003786 D37873 D37874 D37903 D37905 D37907 D37909 D37911 D37913 L17022
GenPept AAA16904 AAH03786 BAA07110 BAA07111 BAA07134 BAA07135 BAA07136 BAA07137 BAA07138 BAA07139
RNA Seq Atlas 14132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca