Version 5.4
Mus musculus Protein: Mpl
Summary
InnateDB Protein IDBP-181594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mpl
Protein Name myeloproliferative leukemia virus oncogene
Synonyms c-mpl; CD110; hlb219; TPO-R;
Species Mus musculus
Ensembl Protein ENSMUSP00000099732
InnateDB Gene IDBG-181592 (Mpl)
Protein Structure
UniProt Annotation
Function Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0032642 regulation of chemokine production
GO:0048872 homeostasis of number of cells
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:97076
InterPro IPR003961 Fibronectin, type III
IPR015152 Growth hormone/erythropoietin receptor, ligand binding
IPR015321 Interleukin-6 receptor alpha, binding
PFAM PF00041
PF01108
PF09067
PF09240
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08351
PhosphoSite PhosphoSite-Q08351
TrEMBL
UniProt Splice Variant
Entrez Gene 17480
UniGene Mm.4864
RefSeq NP_034953
MGI ID
MGI Symbol Mpl
OMIM
CCDS CCDS18552
HPRD
IMGT
EMBL AK041166 AL627212 BC146613 X73677 Z22649 Z22657
GenPept AAI46614 BAC30846 CAA52031 CAA80365 CAA80372 CAM15212

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca