InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mpl

Summary

InnateDB Gene

IDBG-181592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mpl

Gene Name

myeloproliferative leukemia virus oncogene

Synonyms

c-mpl; CD110; hlb219; TPO-R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006389

Encoded Proteins

IDBP-181594

myeloproliferative leukemia virus oncogene

IDBP-181596

myeloproliferative leukemia virus oncogene

IDBP-268893

myeloproliferative leukemia virus oncogene

IDBP-625038

myeloproliferative leukemia virus oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117400:
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:118442415-118457513

Strand

Reverse strand

Band

D2.1

Transcripts

ENSMUST00000102671	ENSMUSP00000099732
ENSMUST00000006556	ENSMUSP00000006556
ENSMUST00000106375	ENSMUSP00000101983
ENSMUST00000168404	ENSMUSP00000130167

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.