InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNAP29

Summary

InnateDB Protein

IDBP-1816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNAP29

Protein Name

synaptosomal-associated protein, 29kDa

Synonyms

CEDNIK; SNAP-29;

Species

Homo sapiens

Ensembl Protein

ENSP00000215730

InnateDB Gene

IDBG-1814 (SNAP29)

Protein Structure

UniProt Annotation

Function

SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Probably involved in multiple membrane trafficking steps. {ECO:0000269PubMed:23217709}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Note=Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic.

Disease Associations

Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK) [MIM:609528]: A neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis and palmoplantar keratoderma. {ECO:0000269PubMed:15968592}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0000046	autophagic vacuole fusion
GO:0006887	exocytosis
GO:0006903	vesicle targeting
GO:0015031	protein transport
GO:0061025	membrane fusion

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0031201	SNARE complex
GO:0043005	neuron projection
GO:0045202	synapse