InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tie1

Summary

InnateDB Protein

IDBP-181623.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tie1

Protein Name

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Synonyms

D430008P04Rik; TIE; tie-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037129

InnateDB Gene

IDBG-181621 (Tie1)

Protein Structure

UniProt Annotation

Function

Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in developing vascular endothelial cells. Abundantly expressed in lung and heart, moderately in brain, liver and kidney, and weakly in thymus, spleen and testis. {ECO:0000269PubMed:8395828}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0006468	protein phosphorylation
GO:0016525	negative regulation of angiogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030336	negative regulation of cell migration
GO:0032526	response to retinoic acid
GO:0045026	plasma membrane fusion

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:99906

InterPro

IPR000719 Protein kinase domain
IPR000742 Epidermal growth factor-like domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013151 Immunoglobulin
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00008
PF07714
PF00041
PF01108
PF00047

PRINTS

PR00109

PIRSF

SMART

SM00181
SM00220
SM00409
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt