InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hipk1

Summary

InnateDB Protein

IDBP-181650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hipk1

Protein Name

homeodomain interacting protein kinase 1

Synonyms

1110062K04Rik; Myak;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029438

InnateDB Gene

IDBG-181648 (Hipk1)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. {ECO:0000269PubMed:12702766, ECO:0000269PubMed:16917507, ECO:0000269PubMed:20231426, ECO:0000269PubMed:20579985}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with high levels in reproductive tissues. Expressed in the epithelial layer of mammary gland, uterus and epididymis, in the corpus luteum, and in post- meiotic round spermatids. {ECO:0000269PubMed:10694743, ECO:0000269PubMed:12529400}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007224	smoothened signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842	retina layer formation
GO:0016926	protein desumoylation
GO:0030182	neuron differentiation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043388	positive regulation of DNA binding
GO:0048596	embryonic camera-type eye morphogenesis
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0060235	lens induction in camera-type eye
GO:0061072	iris morphogenesis
GO:0072577	endothelial cell apoptotic process
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016605	PML body
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

MGI:1314873

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt