InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde11a

Summary

InnateDB Protein

IDBP-181684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde11a

Protein Name

phosphodiesterase 11A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097572

InnateDB Gene

IDBG-181682 (Pde11a)

Protein Structure

UniProt Annotation

Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis and developing spermatoza. {ECO:0000269PubMed:15800654}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0046069	cGMP catabolic process

Cellular Component

GO:0005829	cytosol
GO:0043204	perikaryon

Protein Structure and Domains

PDB ID

MGI:3036251

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003018 GAF domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
IPR029016 GAF domain-like

PFAM

PF00233
PF01590
PF13185
PF13492

PRINTS

PR00387

PIRSF

SMART

SM00065
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt