InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde11a

Summary

InnateDB Gene

IDBG-181682.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde11a

Gene Name

phosphodiesterase 11A

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000075270

Encoded Proteins

IDBP-181684

phosphodiesterase 11A

IDBP-541791

phosphodiesterase 11A

IDBP-542274

phosphodiesterase 11A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128655:
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:75989141-76338774

Strand

Reverse strand

Band

Transcripts

ENSMUST00000099992	ENSMUSP00000097572
ENSMUST00000124825	ENSMUSP00000117451
ENSMUST00000144892	ENSMUSP00000115662

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity