InnateDB Protein
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IDBP-181759.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dclre1b
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Protein Name
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DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000029435
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InnateDB Gene
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IDBG-181757 (Dclre1b)
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Protein Structure
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Function |
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. {ECO:0000269PubMed:20551906, ECO:0000269PubMed:20619712}.
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Subcellular Localization |
Chromosome, telomere {ECO:0000269PubMed:20551906, ECO:0000269PubMed:20619712}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2156057
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InterPro |
IPR001279
Beta-lactamase-like
IPR011084
DNA repair metallo-beta-lactamase
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PFAM |
PF00753
PF07522
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PRINTS |
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PIRSF |
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SMART |
SM00849
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C7W7
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PhosphoSite |
PhosphoSite-Q8C7W7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
140917
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UniGene |
Mm.412294
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RefSeq |
NP_598626
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MGI ID |
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MGI Symbol |
Dclre1b
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OMIM |
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CCDS |
CCDS17694
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HPRD |
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IMGT |
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EMBL |
AK046571
AK049115
AK084347
AK134324
AK137495
AK138568
AK154124
BC011094
BC067017
BC125277
CU210953
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GenPept |
AAH11094
AAH67017
AAI25278
BAC32791
BAC33550
BAC39165
BAE22098
BAE23379
BAE23700
BAE32389
CAQ12168
CAQ12169
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