InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: D10Wsu52e

Summary

InnateDB Protein

IDBP-181767.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

D10Wsu52e

Protein Name

DNA segment, Chr 10, Wayne State University 52, expressed

Synonyms

AI255213; AI463255; D10Wsu52e; FAAP; HSPC117;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001834

InnateDB Gene

IDBG-181765 (D10Wsu52e)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity). Essential during post-implantation development of embryos. {ECO:0000250, ECO:0000269PubMed:20510672}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000255HAMAP-Rule:MF_03144, ECO:0000269PubMed:18508721}. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highly expressed in the epididymis with predominant enrichment in the initial segment. During sexual maturation, it is expressed in the caput epididymides. {ECO:0000269PubMed:21046479}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003972	RNA ligase (ATP) activity
GO:0005524	ATP binding
GO:0008452	RNA ligase activity
GO:0017166	vinculin binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006396	RNA processing