InnateDB Protein
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IDBP-18185.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PIAS4
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Protein Name
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protein inhibitor of activated STAT, 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262971
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InnateDB Gene
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IDBG-18183 (PIAS4)
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Protein Structure
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Function |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269PubMed:12511558, ECO:0000269PubMed:12631292, ECO:0000269PubMed:12727872, ECO:0000269PubMed:15831457, ECO:0000269PubMed:15976810, ECO:0000269PubMed:21965678, ECO:0000269PubMed:22508508}.
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Subcellular Localization |
Nucleus, PML body {ECO:0000269PubMed:11248056, ECO:0000269PubMed:12727872, ECO:0000269PubMed:15831457}. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. {ECO:0000269PubMed:11439351}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
136
[view]
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Protein-Protein |
135
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0016055
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Wnt signaling pathway
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GO:0016925
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protein sumoylation
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GO:0032088
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negative regulation of NF-kappaB transcription factor activity
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GO:0033235
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positive regulation of protein sumoylation
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GO:0045087
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innate immune response (InnateDB)
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:1902174
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positive regulation of keratinocyte apoptotic process
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GO:1902231
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positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
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Cellular Component |
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PDB ID |
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InterPro |
IPR003034
SAP domain
IPR004181
Zinc finger, MIZ-type
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PFAM |
PF02037
PF02891
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PRINTS |
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PIRSF |
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SMART |
SM00513
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N2W9
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PhosphoSite |
PhosphoSite-Q8N2W9
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TrEMBL |
Q05DS6
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UniProt Splice Variant |
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Entrez Gene |
51588
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UniGene |
Hs.619701
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RefSeq |
NP_056981
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HUGO |
HGNC:17002
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OMIM |
605989
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CCDS |
CCDS12118
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HPRD |
06910
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IMGT |
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EMBL |
AF077952
AF164437
BC004389
BC010047
BC029874
BC066895
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GenPept |
AAC36703
AAD45155
AAH04389
AAH10047
AAH29874
AAH66895
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