InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RX1

Summary

InnateDB Protein

IDBP-18188.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RX1

Protein Name

purinergic receptor P2X, ligand-gated ion channel, 1

Synonyms

P2X1;

Species

Homo sapiens

Ensembl Protein

ENSP00000225538

InnateDB Gene

IDBG-18186 (P2RX1)

Protein Structure

UniProt Annotation

Function

Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0008270	zinc ion binding

Biological Process

GO:0002554	serotonin secretion by platelet
GO:0003056	regulation of vascular smooth muscle contraction
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006940	regulation of smooth muscle contraction
GO:0007165	signal transduction
GO:0007320	insemination
GO:0007596	blood coagulation
GO:0008217	regulation of blood pressure
GO:0010033	response to organic substance
GO:0019228	neuronal action potential
GO:0019229	regulation of vasoconstriction
GO:0030168	platelet activation
GO:0033198	response to ATP
GO:0035249	synaptic transmission, glutamatergic
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0042310	vasoconstriction
GO:0043270	positive regulation of ion transport
GO:0046513	ceramide biosynthetic process
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization
GO:0051924	regulation of calcium ion transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031240	external side of cell outer membrane
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0045211	postsynaptic membrane