Version 5.4
Homo sapiens Gene: P2RX1
Summary
InnateDB Gene IDBG-18186.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX1
Gene Name purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms P2X1
Species Homo sapiens
Ensembl Gene ENSG00000108405
Encoded Proteins
IDBP-18188
purinergic receptor P2X, ligand-gated ion channel, 1
IDBP-759248
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:3896592-3916500
Strand Reverse strand
Band p13.2
Transcripts
ENST00000225538 ENSP00000225538
ENST00000576764
ENST00000571637 ENSP00000460449
ENST00000572418
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
Biological Process
GO:0002554 serotonin secretion by platelet
GO:0003056 regulation of vascular smooth muscle contraction
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006940 regulation of smooth muscle contraction
GO:0007165 signal transduction
GO:0007320 insemination
GO:0007596 blood coagulation
GO:0008217 regulation of blood pressure
GO:0010033 response to organic substance
GO:0019228 neuronal action potential
GO:0019229 regulation of vasoconstriction
GO:0030168 platelet activation
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0035249 synaptic transmission, glutamatergic
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042310 vasoconstriction
GO:0043270 positive regulation of ion transport
GO:0046513 ceramide biosynthetic process
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:0051924 regulation of calcium ion transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0031240 external side of cell outer membrane
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020787
View Gene Order
ENSBTAG00000007169
Not yet available
Pathways
NETPATH
REACTOME
REACT_162
Elevation of cytosolic Ca2+ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_604
Hemostasis pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.41735
RefSeq NM_002558
HUGO
OMIM
CCDS CCDS11040
HPRD 07526
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca