Homo sapiens Gene: P2RX1

Summary
InnateDB Gene IDBG-18186.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol P2RX1
Gene Name purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms P2X1
Species Homo sapiens
Ensembl Gene ENSG00000108405
Encoded Proteins
IDBP-18188 purinergic receptor P2X, ligand-gated ion channel, 1
IDBP-759248
Entrez Gene
Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 3799886-3819794
Strand Reverse strand
Band p13.2
Transcripts
ENST00000225538  ENSP00000225538
ENST00000576764 
ENST00000571637  ENSP00000460449
ENST00000572418 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0001614 purinergic nucleotide receptor activity
GO:0004872 receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
Biological Process
GO:0002554 serotonin secretion by platelet
GO:0003056 regulation of vascular smooth muscle contraction
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006940 regulation of smooth muscle contraction
GO:0007165 signal transduction
GO:0007320 insemination
GO:0007596 blood coagulation
GO:0008217 regulation of blood pressure
GO:0010033 response to organic substance
GO:0016265 death
GO:0019228 regulation of action potential in neuron
GO:0019229 regulation of vasoconstriction
GO:0030168 platelet activation
GO:0033198 response to ATP
GO:0035249 synaptic transmission, glutamatergic
GO:0042310 vasoconstriction
GO:0043270 positive regulation of ion transport
GO:0046513 ceramide biosynthetic process
GO:0050896 response to stimulus
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:0051924 regulation of calcium ion transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral to plasma membrane
GO:0016020 membrane
GO:0031240 external side of cell outer membrane
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000020787 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000007169 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_162 Elevation of cytosolic Ca2+ levels
REACT_23876 Platelet homeostasis
KEGG
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P51575 
TrEMBL D3DTJ7 I3L3H3 Q6PIW1 Q71UK3
UniProt Splice Variant
Entrez Gene 5023 
UniGene Hs.41735
RefSeq NM_002558 
HUGO 8533 
OMIM 600845
CCDS CCDS11040 
HPRD 07526
IMGT
EMBL AC005940 AF020498 AF078925 AF177472 BC027949 BC044657 CH471108 U45448 X83688
GenPept AAC24494  AAC32187  AAC50698  AAD55395  AAH27949  AAH44657  CAA58657  EAW90471  EAW90472 
ImmGen P2RX1 (murine) 
RNA Seq Atlas 5023