InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map2k3

Summary

InnateDB Protein

IDBP-182022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map2k3

Protein Name

mitogen-activated protein kinase kinase 3

Synonyms

AW212142; MEK3; MKK3; mMKK3b; Prkmk3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019076

InnateDB Gene

IDBG-182020 (Map2k3)

Protein Structure

UniProt Annotation

Function

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0042035	regulation of cytokine biosynthetic process
GO:0045860	positive regulation of protein kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1346868

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt