InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Map2k3

Summary

InnateDB Gene

IDBG-182020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map2k3

Gene Name

mitogen-activated protein kinase kinase 3

Synonyms

AW212142; MEK3; MKK3; mMKK3b; Prkmk3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018932

Encoded Proteins

IDBP-182022

mitogen-activated protein kinase kinase 3

IDBP-540518

mitogen-activated protein kinase kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 7839144

[Homo sapiens] Activates MAPK14 (p38) MAP kinases

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000034152:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:60932033-60952811

Strand

Forward strand

Band

Transcripts

ENSMUST00000019076	ENSMUSP00000019076
ENSMUST00000145828
ENSMUST00000137739
ENSMUST00000130269	ENSMUSP00000114430
ENSMUST00000126043
ENSMUST00000137609

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0042035	regulation of cytokine biosynthetic process
GO:0045860	positive regulation of protein kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060048	cardiac muscle contraction