InnateDB Protein
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IDBP-182025.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Timp3
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Protein Name
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tissue inhibitor of metalloproteinase 3
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Synonyms
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Timp-3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000020234
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InnateDB Gene
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IDBG-182023 (Timp3)
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Protein Structure
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Function |
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix.
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Disease Associations |
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Tissue Specificity |
Highest levels are found in kidney, lung and brain followed by ovary and uterus. Low levels are found in bone.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
GO:0010951
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negative regulation of endopeptidase activity
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GO:0051045
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negative regulation of membrane protein ectodomain proteolysis
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GO:0071310
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cellular response to organic substance
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Cellular Component |
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PDB ID |
MGI:98754
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InterPro |
IPR001134
Netrin domain
IPR001820
Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
IPR008993
Tissue inhibitor of metalloproteinases-like, OB-fold
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PFAM |
PF00965
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PRINTS |
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PIRSF |
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SMART |
SM00206
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TIGRFAMs |
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Modification |
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SwissProt |
P39876
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q6GXA7
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UniProt Splice Variant |
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Entrez Gene |
21859
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UniGene |
Mm.4871
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RefSeq |
NP_035725
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MGI ID |
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MGI Symbol |
Timp3
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OMIM |
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CCDS |
CCDS24097
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HPRD |
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IMGT |
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EMBL |
AB041611
AK083905
AK147847
AY622855
BC014713
CH466539
L19622
L27424
U26433
U26434
U26435
U26436
U26437
Z30970
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GenPept |
AAA40447
AAA85860
AAC37669
AAH14713
AAT46410
BAA95094
BAC39055
BAE28178
CAA83218
EDL21437
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