InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsp90b1

Summary

InnateDB Protein

IDBP-182080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsp90b1

Protein Name

heat shock protein 90, beta (Grp94), member 1

Synonyms

endoplasmin; ERp99; gp96; GRP94; TA-3; Targ2; Tra-1; Tra1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020238

InnateDB Gene

IDBG-182078 (Hsp90b1)

Protein Structure

UniProt Annotation

Function

Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000269PubMed:20865800}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019903	protein phosphatase binding
GO:0046790	virion binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0051082	unfolded protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0006457	protein folding
GO:0006950	response to stress
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031247	actin rod assembly
GO:0043066	negative regulation of apoptotic process
GO:0043666	regulation of phosphoprotein phosphatase activity
GO:0045087	innate immune response (InnateDB)
GO:0071318	cellular response to ATP

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0042470	melanosome
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:98817

InterPro

IPR001404 Heat shock protein Hsp90 family
IPR003594 Histidine kinase-like ATPase, ATP-binding domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR020575 Heat shock protein Hsp90, N-terminal

PFAM

PF00183
PF02518
PF13581

PRINTS

PR00775

PIRSF

PIRSF002583

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References