InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gabbr1

Summary

InnateDB Protein

IDBP-182143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabbr1

Protein Name

gamma-aminobutyric acid (GABA) B receptor, 1

Synonyms

bM573K1.1; GABAB1; GABAbR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025338

InnateDB Gene

IDBG-182141 (Gabbr1)

Protein Structure

UniProt Annotation

Function

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. {ECO:0000269PubMed:10773016}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in neuronal tissue including cortex, cerebellum and spinal cord. Not detected in non-neuronal tissues including heart, liver, spleen and kidney. {ECO:0000269PubMed:11306808}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004965	G-protein coupled GABA receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007214	gamma-aminobutyric acid signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0038037	G-protein coupled receptor dimeric complex
GO:0038039	G-protein coupled receptor heterodimeric complex
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1860139

InterPro

IPR000436 Sushi/SCR/CCP
IPR001828 Extracellular ligand-binding receptor
IPR002455 GPCR, family 3, gamma-aminobutyric acid receptor, type B
IPR002456 GPCR, family 3, gamma-aminobutyric acid receptor, type B1
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF00084
PF01094
PF00003

PRINTS

PR01177

PIRSF

SMART

SM00032

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt