InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H2-M3

Summary

InnateDB Protein

IDBP-182405.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

H2-M3

Protein Name

histocompatibility 2, M region locus 3

Synonyms

H-2M3; Hmt; M3a; R4B2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035687

InnateDB Gene

IDBG-182403 (H2-M3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042605	peptide antigen binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002237	response to molecule of bacterial origin
GO:0002287	alpha-beta T cell activation involved in immune response
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002477	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0032729	positive regulation of interferon-gamma production
GO:0042742	defense response to bacterium
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity

Cellular Component

GO:0009897	external side of plasma membrane
GO:0032398	MHC class Ib protein complex
GO:0042612	MHC class I protein complex

Protein Structure and Domains

PDB ID

MGI:95915

InterPro

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein
IPR027648 MHC class I alpha chain

PFAM

PF00129
PF07654

PRINTS

PR01638

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt