Version 5.4
Homo sapiens Protein: CLEC12A
Summary
InnateDB Protein IDBP-18241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC12A
Protein Name C-type lectin domain family 12, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000347916
InnateDB Gene IDBG-18239 (CLEC12A)
Protein Structure
UniProt Annotation
Function Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269PubMed:14739280, ECO:0000269PubMed:16239426}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:14739280, ECO:0000269PubMed:15548716, ECO:0000269PubMed:16239426, ECO:0000269PubMed:16838277}; Single-pass type II membrane protein {ECO:0000269PubMed:14739280, ECO:0000269PubMed:15548716, ECO:0000269PubMed:16239426, ECO:0000269PubMed:16838277}. Note=Ligand binding leads to internalization.
Disease Associations
Tissue Specificity Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages. {ECO:0000269PubMed:14739280, ECO:0000269PubMed:15548716, ECO:0000269PubMed:16239426, ECO:0000269PubMed:16838277}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5QGZ9
PhosphoSite PhosphoSite-Q5QGZ9
TrEMBL A8MVL9
UniProt Splice Variant
Entrez Gene 160364
UniGene Hs.190519
RefSeq NP_001193939
HUGO HGNC:31713
OMIM 612088
CCDS CCDS55803
HPRD 14719
IMGT
EMBL AC091814 AF247788 AK314001 AY426759 AY498550 AY498551 AY498552 AY547296 BC063424 BC126289 BC126291 CH471094
GenPept AAH63424 AAI26290 AAI26292 AAL95693 AAR84594 AAS00605 AAS00606 AAS00607 AAT11783 BAG36713 EAW96133

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca