InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpm4

Summary

InnateDB Protein

IDBP-182465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpm4

Protein Name

transient receptor potential cation channel, subfamily M, member 4

Synonyms

1110030C19Rik; AW047689; LTrpC-4; LTRPC4; TRPM4B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040367

InnateDB Gene

IDBG-182463 (Trpm4)

Protein Structure

UniProt Annotation

Function

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway (By similarity). Essential for the migration but not the maturation of dendritic cells. {ECO:0000250, ECO:0000269PubMed:17188667, ECO:0000269PubMed:18758465}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12893253}; Multi-pass membrane protein {ECO:0000269PubMed:12893253}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}.

Disease Associations

Tissue Specificity

Sino-atrial nodes (at protein level). Widely expressed. {ECO:0000269PubMed:12799367, ECO:0000269PubMed:12893253, ECO:0000269PubMed:17188667}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005262	calcium channel activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0002724	regulation of T cell cytokine production
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0008284	positive regulation of cell proliferation
GO:0016925	protein sumoylation
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0090263	positive regulation of canonical Wnt signaling pathway