InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trpm4

Summary

InnateDB Gene

IDBG-182463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpm4

Gene Name

transient receptor potential cation channel, subfamily M, member 4

Synonyms

1110030C19Rik; AW047689; LTrpC-4; LTRPC4; TRPM4B

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038260

Encoded Proteins

IDBP-182465

transient receptor potential cation channel, subfamily M, member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130529:
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45303155-45333780

Strand

Reverse strand

Band

Transcripts

ENSMUST00000042194

ENSMUSP00000040367

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005262	calcium channel activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0002724	regulation of T cell cytokine production
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0008284	positive regulation of cell proliferation
GO:0016925	protein sumoylation
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000130529

View Gene Order

ENSBTAG00000006139

Not yet available

Pathways

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_227861

TRP channels pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

REACT_169333

TRP channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.439890

RefSeq

NM_175130 XM_006541146 XM_006541147 XM_006541149

OMIM

CCDS

CCDS52245

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas