Mus musculus Protein: Sh3kbp1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-182479.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Sh3kbp1 | ||||||||||||||||||||||
Protein Name | SH3-domain kinase binding protein 1 | ||||||||||||||||||||||
Synonyms | 1200007H22Rik; 1700125L08Rik; 5830464D22Rik; AI447724; IN85; Ruk; Seta; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000079257 | ||||||||||||||||||||||
InnateDB Gene | IDBG-182475 (Sh3kbp1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 178 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1889583 | ||||||||||||||||||||||
InterPro |
IPR001452
SH3 domain IPR011511 Variant SH3 domain IPR013315 Spectrin alpha chain, SH3 domain |
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PFAM |
PF00018
PF14604 PF07653 |
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PRINTS |
PR00452
PR01887 |
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PIRSF | |||||||||||||||||||||||
SMART |
SM00326
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q8R550 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q8R550 | ||||||||||||||||||||||
TrEMBL | Q3TT90 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 58194 | ||||||||||||||||||||||
UniGene | Mm.386582 | ||||||||||||||||||||||
RefSeq | NP_067364 | ||||||||||||||||||||||
MGI ID | 2DA9 | ||||||||||||||||||||||
MGI Symbol | Sh3kbp1 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS41194 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF243508 AF472304 AF472305 AF472306 AF472307 AF472308 AF472309 AF472310 AF472311 AF472312 AF472313 AF472314 AF472315 AF472316 AF472317 AF472318 AF472319 AF472320 AF472321 AF472322 AF472323 AF472324 AF472325 AF472326 AF472327 AI428677 AK004636 AK020782 AK038540 AK049182 AK142295 AK161512 AK161735 AL672284 AL683803 AL929452 BX548017 | ||||||||||||||||||||||
GenPept | AAF68439 AAL82456 AAL82457 AAL82458 AAL82459 AAL82460 AAL82461 AAL82462 BAB23427 BAB32209 BAC30033 BAC33592 BAE25017 BAE36435 BAE36553 CAM21669 CAM21670 | ||||||||||||||||||||||