InnateDB Protein
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IDBP-182522.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Arl2bp
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Protein Name
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ADP-ribosylation factor-like 2 binding protein
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Synonyms
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1700010P10Rik; 1700027H16Rik; 6330544B05Rik; AI482273; AI849834; BART; Bart1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034228
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InnateDB Gene
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IDBG-182520 (Arl2bp)
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Protein Structure
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Function |
Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:23849777}. Mitochondrion intermembrane space {ECO:0000269PubMed:23849777}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:23849777}. Note=Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with most abundant activity in brain, especially in hippocampus and cortex. Also expressed in lung, cerebellum, liver, kidney, retina, spleen, muscle and heart (at protein level). {ECO:0000269PubMed:10488091, ECO:0000269PubMed:11809823, ECO:0000269PubMed:18234692, ECO:0000269PubMed:23849777}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0042517
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positive regulation of tyrosine phosphorylation of Stat3 protein
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GO:0050790
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regulation of catalytic activity
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GO:0051457
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maintenance of protein location in nucleus
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GO:2001141
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regulation of RNA biosynthetic process
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Cellular Component |
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PDB ID |
MGI:1349429
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InterPro |
IPR023379
ADP-ribosylation factor-like 2-binding protein, domain
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PFAM |
PF11527
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D385
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PhosphoSite |
PhosphoSite-Q9D385
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
107566
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UniGene |
Mm.488471
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RefSeq |
NP_077153
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MGI ID |
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MGI Symbol |
Arl2bp
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OMIM |
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CCDS |
CCDS22545
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HPRD |
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IMGT |
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EMBL |
AK006418
AK006646
AK018229
AK155242
AK161325
BC002131
BC024708
CT010168
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GenPept |
AAH02131
AAH24708
BAB24578
BAB24686
BAB31126
BAE33143
BAE36323
CAJ18376
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