InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP2A3

Summary

InnateDB Protein

IDBP-18256.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2A3

Protein Name

ATPase, Ca++ transporting, ubiquitous

Synonyms

SERCA3;

Species

Homo sapiens

Ensembl Protein

ENSP00000301387

InnateDB Gene

IDBG-18252 (ATP2A3)

Protein Structure

UniProt Annotation

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269PubMed:11956212, ECO:0000269PubMed:15028735}.

Subcellular Localization

Nucleus membrane {ECO:0000269PubMed:15028735}; Multi-pass membrane protein {ECO:0000269PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269PubMed:15028735}; Multi-pass membrane protein {ECO:0000269PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269PubMed:15028735}; Multi-pass membrane protein {ECO:0000269PubMed:15028735}.

Disease Associations

Tissue Specificity

Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. {ECO:0000269PubMed:11956212, ECO:0000269PubMed:15028735}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031095	platelet dense tubular network membrane
GO:0031965	nuclear membrane
GO:0033017	sarcoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005782 Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt