InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 1190002H23Rik

Summary

InnateDB Protein

IDBP-182582.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

1190002H23Rik

Protein Name

RIKEN cDNA 1190002H23 gene

Synonyms

1190002H23Rik; Rgc-32; Rgc32;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022595

InnateDB Gene

IDBG-182580 (1190002H23Rik)

Protein Structure

UniProt Annotation

Function

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269PubMed:21990365}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity
GO:0070412	R-SMAD binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001100	negative regulation of exit from mitosis
GO:0001937	negative regulation of endothelial cell proliferation
GO:0003331	positive regulation of extracellular matrix constituent secretion
GO:0006956	complement activation
GO:0008285	negative regulation of cell proliferation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016525	negative regulation of angiogenesis
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032967	positive regulation of collagen biosynthetic process
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0045840	positive regulation of mitosis
GO:0050710	negative regulation of cytokine secretion
GO:0050715	positive regulation of cytokine secretion
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051496	positive regulation of stress fiber assembly
GO:0071158	positive regulation of cell cycle arrest
GO:0071456	cellular response to hypoxia
GO:0071850	mitotic cell cycle arrest
GO:0072537	fibroblast activation
GO:0090272	negative regulation of fibroblast growth factor production
GO:1901313	positive regulation of gene expression involved in extracellular matrix organization
GO:1901991	negative regulation of mitotic cell cycle phase transition
GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2000573	positive regulation of DNA biosynthetic process