Version 5.4
Mus musculus Gene: 1190002H23Rik
Summary
InnateDB Gene IDBG-182580.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol 1190002H23Rik
Gene Name RIKEN cDNA 1190002H23 gene
Synonyms 1190002H23Rik; Rgc-32; Rgc32
Species Mus musculus
Ensembl Gene ENSMUSG00000022018
Encoded Proteins
IDBP-182582
RIKEN cDNA 1190002H23 gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102760:
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:79288756-79301645
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000022595 ENSMUSP00000022595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030295 protein kinase activator activity
GO:0070412 R-SMAD binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001100 negative regulation of exit from mitosis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0003331 positive regulation of extracellular matrix constituent secretion
GO:0006956 complement activation
GO:0008285 negative regulation of cell proliferation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016525 negative regulation of angiogenesis
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032967 positive regulation of collagen biosynthetic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045840 positive regulation of mitosis
GO:0050710 negative regulation of cytokine secretion
GO:0050715 positive regulation of cytokine secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051496 positive regulation of stress fiber assembly
GO:0071158 positive regulation of cell cycle arrest
GO:0071456 cellular response to hypoxia
GO:0071850 mitotic cell cycle arrest
GO:0072537 fibroblast activation
GO:0090272 negative regulation of fibroblast growth factor production
GO:1901313 positive regulation of gene expression involved in extracellular matrix organization
GO:1901991 negative regulation of mitotic cell cycle phase transition
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102760
View Gene Order
ENSBTAG00000034885
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt Q9DBX1
TrEMBL
UniProt Splice Variant
Entrez Gene 66214
UniGene
RefSeq NM_025427 XM_006519373
OMIM
CCDS CCDS49552
HPRD
IMGT
MGI ID MGI:1913464
MGI Symbol Rgcc
EMBL AF276981 AK004451 AK004705 BC049580 BC050935 CT010403
GenPept AAH49580 AAH50935 AAK69442 BAB23310 BAB23490 CAJ18609
RNA Seq Atlas 66214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca