InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il31ra

Summary

InnateDB Protein

IDBP-182605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il31ra

Protein Name

interleukin 31 receptor A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058045

InnateDB Gene

IDBG-182603 (Il31ra)

Protein Structure

UniProt Annotation

Function

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. {ECO:0000269PubMed:15184896}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in skin, testis, bone marrow and thymus. In the nervous system, expressed specifically by a subset of dorsal root ganglia (at protein level). {ECO:0000269PubMed:15184896, ECO:0000269PubMed:16926070}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0007259	JAK-STAT cascade
GO:0008284	positive regulation of cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0030224	monocyte differentiation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein