InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elf1

Summary

InnateDB Protein

IDBP-182874.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elf1

Protein Name

E74-like factor 1

Synonyms

Elf-1; mElf-1; p70; Sts1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046515

InnateDB Gene

IDBG-182872 (Elf1)

Protein Structure

UniProt Annotation

Function

Transcription factor that activates the LYN and BLK promoters. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Predominantly found in hematopoietic cells. Detected in other cell types such as fibroblasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	7 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050860	negative regulation of T cell receptor signaling pathway