Version 5.4
Mus musculus Gene: Elf1
Summary
InnateDB Gene IDBG-182872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elf1
Gene Name E74-like factor 1
Synonyms Elf-1; mElf-1; p70; Sts1
Species Mus musculus
Ensembl Gene ENSMUSG00000036461
Encoded Proteins
IDBP-182874
E74-like factor 1
IDBP-259401
E74-like factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21867680
Elf1 transcription factor negatively regulates Tollip, a negative regulator of Toll-like receptor (TLR) signalling, in response to O-linked N-acetylglucosamine (O-GlcNAc) modification. In intestinal epithelial cells insufficient O-GlcNAc modification prevents Elf1-mediated transcriptional repression and thereby suppresses TLR signalling via upregulated Tollip gene expression. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 21867680
[Homo sapiens] ELF1 transcription factor negatively regulates TOLLIP, a negative regulator of Toll-like receptor (TLR) signalling, in response to O-linked N-acetylglucosamine (O-GlcNAc) modification. In intestinal epithelial cells, insufficient O-GlcNAc modification prevents ELF1-mediated transcriptional repression and thereby suppresses TLR signalling via upregulated TOLLIP gene expression.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120690:
This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:79481194-79582476
Strand Forward strand
Band D3
Transcripts
ENSMUST00000040131 ENSMUSP00000046515
ENSMUST00000110835 ENSMUSP00000106459
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 7 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050860 negative regulation of T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120690
View Gene Order
ENSBTAG00000007356
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
ap1_pathway
AP-1 transcription factor network
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
Cross-References
SwissProt Q60775
TrEMBL Q3UQ47 Q3V1H4
UniProt Splice Variant
Entrez Gene 13709
UniGene Mm.20938
RefSeq NM_007920 NM_001286411
OMIM
CCDS CCDS27301
HPRD
IMGT
MGI ID MGI:107180
MGI Symbol Elf1
EMBL AK132456 AK142807 BC057134 CH466535 U19617
GenPept AAB17097 AAH57134 BAE21177 BAE25196 EDL35763
RNA Seq Atlas 13709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca