Version 5.4
Mus musculus Protein: Lin54
Summary
InnateDB Protein IDBP-183169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lin54
Protein Name lin-54 homolog (C. elegans)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000041374
InnateDB Gene IDBG-183167 (Lin54)
Protein Structure
UniProt Annotation
Function Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2140902
InterPro IPR005172 CRC domain
PFAM PF03638
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q571G4
PhosphoSite PhosphoSite-Q571G4
TrEMBL B7ZN58
UniProt Splice Variant
Entrez Gene 231506
UniGene Mm.398513
RefSeq NP_766302
MGI ID
MGI Symbol Lin54
OMIM
CCDS CCDS19462
HPRD
IMGT
EMBL AK028016 AK029288 AK134320 AK220225 BC106126 BC125580 BC145025 CH466529
GenPept AAI06127 AAI25581 AAI45026 BAC25700 BAC26373 BAD90150 BAE22096 EDL20292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca