InnateDB Protein
|
IDBP-183252.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Katnb1
|
Protein Name
|
katanin p80 (WD40-containing) subunit B 1
|
Synonyms
|
2410003J24Rik; KAT;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000034239
|
InnateDB Gene
|
IDBG-183250 (Katnb1)
|
Protein Structure
|
|
Function |
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255HAMAP-Rule:MF_03022}.
|
Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000255HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton {ECO:0000255HAMAP-Rule:MF_03022}. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles. {ECO:0000255HAMAP-Rule:MF_03022}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
9 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006200
|
ATP catabolic process
|
GO:0007026
|
negative regulation of microtubule depolymerization
|
GO:0007079
|
mitotic chromosome movement towards spindle pole
|
GO:0010942
|
positive regulation of cell death
|
GO:0010976
|
positive regulation of neuron projection development
|
GO:0031117
|
positive regulation of microtubule depolymerization
|
GO:0051013
|
microtubule severing
|
|
Cellular Component |
|
PDB ID |
MGI:1921437
|
InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
IPR020472
G-protein beta WD-40 repeat
|
PFAM |
PF00400
|
PRINTS |
PR00320
|
PIRSF |
|
SMART |
SM00320
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8BG40
|
PhosphoSite |
PhosphoSite-Q8BG40
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
74187
|
UniGene |
Mm.28382
|
RefSeq |
NP_083081
|
MGI ID |
|
MGI Symbol |
Katnb1
|
OMIM |
|
CCDS |
CCDS22555
|
HPRD |
|
IMGT |
|
EMBL |
AK010364
AK031630
AK034103
AK049345
AK087973
BC024500
BC045200
|
GenPept |
AAH24500
AAH45200
BAB26884
BAC27487
BAC28588
BAC33697
BAC40067
|
|
|