Version 5.4
Mus musculus Gene: Katnb1
Summary
InnateDB Gene IDBG-183250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Katnb1
Gene Name katanin p80 (WD40-containing) subunit B 1
Synonyms 2410003J24Rik; KAT
Species Mus musculus
Ensembl Gene ENSMUSG00000031787
Encoded Proteins
IDBP-183252
katanin p80 (WD40-containing) subunit B 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140854:
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:95081201-95099874
Strand Forward strand
Band C5
Transcripts
ENSMUST00000034239 ENSMUSP00000034239
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008568 microtubule-severing ATPase activity
GO:0045502 dynein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006200 ATP catabolic process
GO:0007026 negative regulation of microtubule depolymerization
GO:0007079 mitotic chromosome movement towards spindle pole
GO:0010942 positive regulation of cell death
GO:0010976 positive regulation of neuron projection development
GO:0031117 positive regulation of microtubule depolymerization
GO:0051013 microtubule severing
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0008352 katanin complex
GO:0016020 membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140854
View Gene Order
ENSBTAG00000001848
Not yet available
Cross-References
SwissProt Q8BG40
TrEMBL
UniProt Splice Variant
Entrez Gene 74187
UniGene Mm.28382
RefSeq NM_028805 XM_006531410 XM_006531411 XM_006531412 XM_006531413
OMIM
CCDS CCDS22555
HPRD
IMGT
MGI ID MGI:1921437
MGI Symbol Katnb1
EMBL AK010364 AK031630 AK034103 AK049345 AK087973 BC024500 BC045200
GenPept AAH24500 AAH45200 BAB26884 BAC27487 BAC28588 BAC33697 BAC40067
RNA Seq Atlas 74187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca