Version 5.4
Mus musculus Protein: Cops4
Summary
InnateDB Protein IDBP-183287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cops4
Protein Name COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
Synonyms AW208976; D5Ertd774e;
Species Mus musculus
Ensembl Protein ENSMUSP00000048416
InnateDB Gene IDBG-183285 (Cops4)
Protein Structure
UniProt Annotation
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000338 protein deneddylation
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0008021 synaptic vesicle
GO:0008180 COP9 signalosome
GO:0030054 cell junction
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1349414
InterPro IPR000717 Proteasome component (PCI) domain
PFAM PF01399
PRINTS
PIRSF
SMART SM00088
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88544
PhosphoSite PhosphoSite-O88544
TrEMBL Q14AI7
UniProt Splice Variant
Entrez Gene 26891
UniGene Mm.957
RefSeq NP_036131
MGI ID 1UFM
MGI Symbol Cops4
OMIM
CCDS CCDS19463
HPRD
IMGT
EMBL AC109196 AF071314 AK009955 BC116800 BC116826 CH466529
GenPept AAC33901 AAI16801 AAI16827 BAB26607 EDL20290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca